Vaginal progesterone to reduce preterm birth among HIV-infected pregnant women in Zambia: a feasibility study protocol.
Identifieur interne : 000000 ( Main/Exploration ); suivant : 000001Vaginal progesterone to reduce preterm birth among HIV-infected pregnant women in Zambia: a feasibility study protocol.
Auteurs : Joan T. Price [États-Unis] ; Katie R. Mollan [États-Unis] ; Nurain M. Fuseini [États-Unis] ; Bethany L. Freeman [États-Unis] ; Helen B. Mulenga [Zambie] ; Amanda H. Corbett [États-Unis] ; Bellington Vwalika [États-Unis] ; Jeffrey S A. Stringer [États-Unis]Source :
- Pilot and feasibility studies [ 2055-5784 ] ; 2018.
Abstract
Women infected with HIV have a risk of preterm birth (PTB) that is twice that among uninfected women, and treatment with antiretroviral therapy (ART) may further increase this risk. Progesterone supplementation reduces the risk of preterm delivery in women who have a shortened cervix in the midtrimester. We propose to study the feasibility of a trial of vaginal progesterone (VP) to prevent PTB among HIV-infected women receiving ART in pregnancy. Given low adherence among women self-administering vaginal study product in recent microbicide trials, we plan to investigate whether adequate adherence to VP can be achieved prior to launching a full-scale efficacy trial.
DOI: 10.1186/s40814-017-0170-7
PubMed: 28729911
Affiliations:
- Zambie, États-Unis
- Caroline du Nord
- Chapel Hill (Caroline du Nord)
- Université de Caroline du Nord à Chapel Hill
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Freeman</name><affiliation wicri:level="4"><nlm:affiliation>Division of Global Women's Health, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, 3009 Old Clinic Building, Campus Box 7577, Chapel Hill, 27599-7577 NC USA.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><wicri:regionArea>Division of Global Women's Health, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, 3009 Old Clinic Building, Campus Box 7577, Chapel Hill</wicri:regionArea><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Mulenga, Helen B" sort="Mulenga, Helen B" uniqKey="Mulenga H" first="Helen B" last="Mulenga">Helen B. Mulenga</name><affiliation wicri:level="1"><nlm:affiliation>Pharmaceutical Society of Zambia, Lusaka, Zambia.</nlm:affiliation><country xml:lang="fr">Zambie</country><wicri:regionArea>Pharmaceutical Society of Zambia, Lusaka</wicri:regionArea><wicri:noRegion>Lusaka</wicri:noRegion></affiliation></author><author><name sortKey="Corbett, Amanda H" sort="Corbett, Amanda H" uniqKey="Corbett A" first="Amanda H" last="Corbett">Amanda H. Corbett</name><affiliation wicri:level="2"><nlm:affiliation>Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill</wicri:cityArea></affiliation></author><author><name sortKey="Vwalika, Bellington" sort="Vwalika, Bellington" uniqKey="Vwalika B" first="Bellington" last="Vwalika">Bellington Vwalika</name><affiliation wicri:level="4"><nlm:affiliation>Division of Global Women's Health, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, 3009 Old Clinic Building, Campus Box 7577, Chapel Hill, 27599-7577 NC USA.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><wicri:regionArea>Division of Global Women's Health, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, 3009 Old Clinic Building, Campus Box 7577, Chapel Hill</wicri:regionArea><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Stringer, Jeffrey S A" sort="Stringer, Jeffrey S A" uniqKey="Stringer J" first="Jeffrey S A" last="Stringer">Jeffrey S A. Stringer</name><affiliation wicri:level="4"><nlm:affiliation>Division of Global Women's Health, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, 3009 Old Clinic Building, Campus Box 7577, Chapel Hill, 27599-7577 NC USA.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><wicri:regionArea>Division of Global Women's Health, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, 3009 Old Clinic Building, Campus Box 7577, Chapel Hill</wicri:regionArea><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author></analytic><series><title level="j">Pilot and feasibility studies</title><idno type="ISSN">2055-5784</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Women infected with HIV have a risk of preterm birth (PTB) that is twice that among uninfected women, and treatment with antiretroviral therapy (ART) may further increase this risk. Progesterone supplementation reduces the risk of preterm delivery in women who have a shortened cervix in the midtrimester. We propose to study the feasibility of a trial of vaginal progesterone (VP) to prevent PTB among HIV-infected women receiving ART in pregnancy. Given low adherence among women self-administering vaginal study product in recent microbicide trials, we plan to investigate whether adequate adherence to VP can be achieved prior to launching a full-scale efficacy trial.</div></front></TEI><affiliations><list><country><li>Zambie</li><li>États-Unis</li></country><region><li>Caroline du Nord</li></region><settlement><li>Chapel Hill (Caroline du Nord)</li></settlement><orgName><li>Université de Caroline du Nord à Chapel Hill</li></orgName></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Price, Joan T" sort="Price, Joan T" uniqKey="Price J" first="Joan T" last="Price">Joan T. Price</name></region><name sortKey="Corbett, Amanda H" sort="Corbett, Amanda H" uniqKey="Corbett A" first="Amanda H" last="Corbett">Amanda H. Corbett</name><name sortKey="Freeman, Bethany L" sort="Freeman, Bethany L" uniqKey="Freeman B" first="Bethany L" last="Freeman">Bethany L. Freeman</name><name sortKey="Fuseini, Nurain M" sort="Fuseini, Nurain M" uniqKey="Fuseini N" first="Nurain M" last="Fuseini">Nurain M. Fuseini</name><name sortKey="Mollan, Katie R" sort="Mollan, Katie R" uniqKey="Mollan K" first="Katie R" last="Mollan">Katie R. Mollan</name><name sortKey="Stringer, Jeffrey S A" sort="Stringer, Jeffrey S A" uniqKey="Stringer J" first="Jeffrey S A" last="Stringer">Jeffrey S A. Stringer</name><name sortKey="Vwalika, Bellington" sort="Vwalika, Bellington" uniqKey="Vwalika B" first="Bellington" last="Vwalika">Bellington Vwalika</name></country><country name="Zambie"><noRegion><name sortKey="Mulenga, Helen B" sort="Mulenga, Helen B" uniqKey="Mulenga H" first="Helen B" last="Mulenga">Helen B. Mulenga</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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